Why Do Depression and Anxiety Go Together?


[♪ INTRO ] If you’ve ever experienced anxiety and depression
— in the clinical sense, I mean — you’ll know that they can feel really different. With anxiety, you’re all ramped up. And with depression, you’re very, very down. Yet they tend to go together. And a lot of medications, especially certain
types of antidepressants, can be used to treat both. We still don’t know a ton about how exactly
anxiety and depression work in the brain — or how antidepressants work to treat them. But over time, psychologists have come to
realize that the two types of conditions are surprisingly similar. They may feel very different in the moment. But they actually have a lot of symptoms in
common, and involve some very similar thought patterns. They might even have similar brain chemistries. So if you’re looking to understand a little
more about how anxiety and depression manifest themselves — whether for yourself or for
someone else in your life — those connections are a good place to start. Depression and anxiety aren’t really specific
disorders — they’re generic terms for types of disorders. But the most common, and most closely linked,
are major depressive disorder, or MDD, and generalized anxiety disorder, or GAD. In any given year in the U.S., where it’s
easiest to find detailed statistics, about 7% of the population will have MDD, and about
3% will have GAD. Lots of those people have both: About 2/3
of people with major depression also have some kind of anxiety disorder, and about 2/3
of people with generalized anxiety disorder also have major depression. And whether you have one or the other or both,
the same medications are often at the top of the list to help treat it — usually antidepressants. Unsurprisingly, psychologists have noticed
these statistics. But for a long time, we’ve thought of generalized
anxiety and major depression as very different things, and understandably so. Probably the most noticeable symptom of anxiety
is arousal, which in psychology is a technical term rather than a specifically sexual thing. It basically just means being on high alert
— whether psychologically, with increased awareness, or physically, with things like
a racing heart and sweaty palms. Arousal isn’t part of major depression,
though. And there’s a key symptom of MDD that doesn’t
usually show up in generalized anxiety: low positive affect, which is the technical term
for not getting much pleasure out of life and feeling lethargic and just kind of … blah. So there are important differences between
anxiety and depression, which is part of why they’re still considered separate classes
of disorders. But when you look at the other symptoms, you
start to realize that major depression and generalized anxiety have almost everything
else in common. There’s restlessness, fatigue, irritability,
problems with concentration, sleep disturbances … the list goes on. And that’s just in the official diagnostic
criteria. So for decades, psychologists have been examining
the models they use to describe anxiety and depression in the brain to see if they point
to a similar source for both types of disorders. They’ve come up with lots of different ideas,
as researchers do, but the most common ones tend to center around the fight or flight
response to stress. Fight or flight kicks in when you’re confronted
with something your mind sees as a threat, and it automatically prepares you to either
fight or run away. And when you think about it, anxiety and depression
are just different types of flight. Psychologists often characterize anxiety as
a sense of helplessness, at its core, and depression as a sense of hopelessness. Anxiety might feel like you’re looking for
ways to fight back. But part of what makes it a disorder is that
it’s not a short-lived feeling that’s easily resolved once you have a plan. Of course, as with all things mental health,
anxiety disorders can be deeply personal and won’t feel the same for everybody. But clinical anxiety does tend to be more
pervasive. The worry sticks around and starts to take
over your life because it doesn’t feel like something you can conquer. So anxiety and depression might just be slightly
different ways of expressing the same flight response: helplessness or hopelessness. And maybe that’s part of why they so often
go together. That connection also shows up on the biochemical
side of the stress response. There are a lot of hormones involved in this
response, and their effects interact in super complex ways that scientists still don’t
fully understand. But both depressive and anxiety disorders
are closely associated with an oversensitive stress response system. Researchers think that’s one reason both
of these types of disorders are so much more common in people who’ve experienced major
stresses like trauma or childhood abuse. Those stressors could make their stress response
system more sensitive. The main hormones involved aren’t always
the same, but the changes can cause some of the same symptoms — problems with sleep,
for example. So anxiety and depression seem to be two sides
of a similar reaction to stress, in terms of both thought processes and hormones. Still, that doesn’t really explain why some
antidepressants can treat both anxiety and depression. Because those medications primarily affect
neurotransmitters, the molecules your brain cells use to send messages to each other. If you thought we had a lot left to learn
about how the stress response works, we know even less about what the brain chemistry of
anxiety and depression looks like, or how antidepressants help. But if the thought processes and physical
responses that go along with these disorders aren’t quite as different as they seem on
the surface, it makes sense that the brain chemistry would be similar, too. And that’s exactly what scientists have
found. More specifically, lots of studies have pointed
to lower levels of the neurotransmitter known as serotonin as a major factor in both anxiety
and depression. Researchers have even identified some more
specific cellular receptors that seem to be involved in both. There’s also some evidence that the way
the brain handles another neurotransmitter, norepinephrine, can be similar in both anxiety
and depression. Since most antidepressants work by increasing
serotonin levels, and some of them also affect norepinephrine, that could explain why they’re
so helpful for both anxiety and depression. Although again, there’s a lot we don’t
know about their exact mechanisms. Ultimately, there’s no denying that in the
moment, anxiety and depression can seem like very different feelings. And if someone has both types of disorders
— well, it’s easy to see how that could feel overwhelming. Like, it’s hard enough treating generalized
anxiety or major depression on their own. And it’s true that it is often harder to
treat these conditions when someone has both. But maybe not twice as hard. After all, anxiety and depressive disorders
have a lot in common, from their symptoms to the basic brain chemistry behind them to
some of the treatments that can help. The fact that they often go together can be
really tough. But understanding more about why that is has
also pointed us toward better treatments and more effective therapies, that really can
help. Thanks for watching this episode of SciShow
Psych. If you’re looking for someone to talk to about
your mental health, we left a few resources in this video’s description. And if you’d like to learn more general info
about treatments, you can watch our episode on misconceptions about antidepressants. [♪ OUTRO ]

100 comments

  1. ECT , lithium, wellbutrin, klonopin, trazodone… I almost don't want to crawl out of my skin, or harm the world.
    The truth is I don't understand how to be like "you"

  2. My depressed mind cannot catch up with the speed they explain things that i needed to pause this and rewind a couple of times… phew…

  3. Do a vid on SAD, since both I and my mum have it, and we find it strange since we are so lively and energetic in the summer, but tired and sad in the winter.

  4. Psychologists seem to know so little about they're doing. But I've found Transactional Analysis to be very helpful in dealing with people.

  5. My sleep is beyond fucked i can't sleep because i overthink everything at night and people are saying just calm down and let the thoughts pass I CAN'T 😔

  6. Depression: hello I'm depression
    Anxiety: hi I'm anxiety, pleased to meet you depression, let's get together and thoroughly screw with CLARYT…..
    Depression: sounds like a plan.. Let's do it!!

  7. Worse is how crippling depression and anxiety are. They destroy lives as thoroughly as any cancer. But no one, even doctors, seem willing to treat or diagnose it. Everyone has the attitude of "suck it up" but you don't tell an amputee to walk it off, and it wont work with depression ether. Parts of your brain are dead or dying. Just because you cant see it doesn't mean they aren't injured.

  8. Going from an emotionless person to a somewhat sensitive person while under the influence of anti depressants after using it for over 2 months. It didn't help with depression, it just made me weaker as a person and I noticed that I spend more time self-loathing and overthinking than I usually do when not using it. I don't recommend anti depressants for lonely people. Especially if you're like most of us with no friends around, single and live alone. I'm following up with my psychiatrist soon and I'll tell him what's up, let's hope it goes better.

  9. Yea having both is just a weird experience, symptoms that you'd think are not possible to be felt at the same time (or at least close to the same time, or switching between symptoms within a day or even hours or minutes) At the moment I have the sick to my stomach feeling like butterflies, shaking, sweaty palms, but I also have this fluff in my head like I get from depression, and the lack of really finding fun or joy in things and the feeling of things being far away or muted. It's like a big short circut in my brain.

  10. i had depression, the medicines they gave me didnt cure me and worst they made me anxiaty, a super strong anxiaty, the pills were way worst than the depression, now thank god i could leave the pills, the withdrawal was horrible, i feel better but i wont take pills anymore ever! do not take mirtazapine, its worst than the disease!

  11. I'm constantly lethargic from depression and then I drink energy drinks and have panic attacks. Although even without caffeine I am affected by anxiety.

  12. The only video i need is why am I loosing my memory although I m just 22 and why am I always sad and tired all the time even though I don’t have depression necessarily .

  13. When i look at others it feels like they are born with filters,filters that protect them, filters that people like me are missing

  14. I've been feeling sick and somewhat scared for years so I'm going to the doctor soon to find out if I have anxiety, or a physical illness, or maybe a physical illness AND anxiety or a physical illness which causes anxiety. I'm feeling strangely excited to go to the doctor atm. Aaaaand also nervous of course, as you'd expect from someone who possibly has anxiety or is just a sick person who gets nervous often e.e In either case I'm a nervous wreck

  15. "these types of disorders are so much more common in people who've experienced major stresses like trauma or childhood abuse – those stressors could make their stress response system more sensitive" big oof that's me….

  16. this explains how my disorders all affect each other (ptsd, major dep, gen anxiety, adhd), but also makes me wonder if i have each individual disorder and there's symptom crossover or if i only have ptsd, where the symptoms of that can be interpreted as coming from multiple disorders….rambling but i think this makes sense?

  17. I have anxiety and depression. Ive had experience childhood abuse of many kinds but even as an adult I still deal with abusive ppl etc. negative experiences in the long term just makes the disorders much worse.

  18. I have both and they intertwine like dog tails. I'll start panicking, then burst into full blown tears for hours on end, and I mean lik a banshee cream kinds of storm (Yelling,crying, wailing), and after thats gone the stress leaves and in enters depression for about as long as the banshee fit lasted, if not longer.

    The worst was either the time I gave myself a bloody nose from crying so hard or the time I cried for two hours straight and woke up still feeling like my eyes were puffy and my nose was stuffy from crying. I only got 7 hours that night.

  19. Doesn't seem like a difficult question to me. If you're depressed, things aren't going well. If things aren't gong well, we tend to get anxious. Isn't that kind of obvious?

  20. Anxiety, depression and almost every other mental illness are entirely caused by environmental factors, mostly diet.
    It took me six years of non stop research and testing on myself to cure my depression, and when my anxiety went away I realised that the background fear I always experienced wasn't my personality.
    Gluten, low quality dairy and processed and/or factory farmed animal flesh and unfiltered tap water are some of the major causes.

    A raw, vegan, sugar-free, grain-free, lightly ketogenic diet with intermittent fasting will reverse symptoms as fast as possible, depending on your own personal health, and there are many proven herbs that can alleviate your symptoms while your body heals.

    Rhodiola Rosea for energy and antidepressant qualities, Ashwagandha to heal your fried adrenals, velvet Bean to increase dopamine, Valerian for anti-anxiety, sleep and muscle relaxing, Dandelion for detoxing the body, etc etc.
    I'm no herb expert, I don't need to be there's millions of them, however very few people know how to eat their health properly.
    John Rose is one.

  21. People who does understand how anxiety works will just call you a coward and if you’re depressed they will ask you :”What’s wrong?” Or say :”cheer up!”

  22. I have both anxiety is worse I’m happy for that I worry less about eventually becoming suicidal though anxiety just makes me extremely angry at random times just thinking about my stressors

  23. Anxiety makes you fight. This fight can cost you your marriage, house, friends, and family.

    Then you have no one or anything to fight for. The flight is to disconnect and go into basic survival mode.

    In the end you reach out to family and friends that think you are lazy or don't love them. It's "treatable" I hear a lot.

    I don't know of many people with treatable major health issues that have no will to live survive.

  24. SSRI ruined my life!! Do not try SSRI!! Try adderall instead, it saved my life. I just saved countless lives, your welcome.

  25. anxiety: hAh let’s worry about everything and shut ourselves off because i don’t want everyone to hate me
    depression: everyone hates me and nobody wants me around so it’s for the best for me to shut myself off because everyone already hates me. nobody would even care if i died…
    me: okay ouch

  26. The speaker has made countless references to "medications" that help anxiety and depression. Physicians are in general taught to prescribe antidepressants for both anxiety and depression. I know because I practiced Internal Medicine for 40 years and am now retired. I can say what I have learned but this obviously does not constitute formal advice to any particular person/s.
    1. Antidepressants in the vast majority of people, have awful side effects.
    2. They are brain altering in unknown ways; they can change your personality.
    3. This nonsense about "chemical imbalances" of serotonin and/or nor-epinephrine are just concepts/creations by drug companies which have overwhelmed the field of psychiatry; there is not a shred of evidence proving these "imbalances."
    4. Most psychiatry visits involve dealing with psychiatric drugs. Try this, then this then this and so on. Often a second drug is used to deal with the side effects of the first one. Not better with one drug? No problem stay with it and we'll add a second and third drug. Why was the useless one not stopped? Because then the psychiatrist would have to deal with the withdrawal from that one.
    5. It is a constant trial and error thing with these psychiatric meds.
    6. Antidepressants are extremely addicting and it is proven that it can take more than a year, sometimes a few years, to get off a single antidepressant.
    7. Mild anxiety can be helped by benzodiazepines (Xanax, Valium etc) but the medical profession got burned by people indulging in those drugs (recreational drugs) so much years ago that they are avoided by physicians. People taking even just two doses a day to deal with anxiety, and stable in such a low dosage, even if doing well, are being told that they need to stop and switch to an antidepressant. Which causes ten times the dependence of a low dose benzodiazepine.
    8. Antidepressants can really increase suicidal tendencies. And I suspect, homicidal tendencies. With easy availability of guns, we are in a crisis situation in this regard.
    9. In the past few years, there has been a reckless use of anti-psychotic drugs by psychiatrists on people with anxiety/depression.

    Bottom line is that antidepressants and anti-psychotic drugs are the most dangerous drugs that humanity has ever been exposed to; they don't cure any psychiatric disorders, they just drug people up. Humanity needs to explore mindfulness practice, establish with kind and understanding counselors, involve family, exercise more, learn stress management, cut out sugar and stimulants in their diet, and so on. Lastly, putting children on stimulants for attention deficit disorder ought to be considered criminal activity. The drugging of humanity has now started in childhood.

  27. Thank you for this video. My depression is horrific. I'm getting help, but nothing is getting better. I never thought I'd be like this.

  28. I can tell you exactly how anxiety and depression work together. If you feel anxious and on the verge of a panic attack all the time it can make you hate life. When you hate life you wanna die to end the pain. That's how they're related

  29. I have major depressive disorder and and multiple anxiety disorders like health /illness anxiety disorder social anxiety disorder panic disorder and had a variety of anti-depressants and tranquilizers over the years and I am talking over 30 years and as usual we get the ones who think they can make asumptions like I have bipolar or as it used to be called manic -depression despite over the years doctors repeatily having to say I do not have manic -depression or any other psychotic illness and nor do I ever want to as what I do suffer from is bad enough what I have is neurotic based has anybody else hade amatuers in nothing thinking oh he must have such and such and I am talking about local councils to the point where I have litrually had to get doctors to write letters saying I am NOT psychotic my point is they think if you have a mental heath problem you must be mad that thereis only one form of so-called mental illness when there are many at various degreses

  30. as I mentioned in my previous comments about different conditions well could society finally give up the stigma of mental health or to be precise mental ill health stop dehumanizing people including myself and relize it is all too human we are people like them treat others as you wish to be treated

  31. Why are you talking so fast? Please slow down your delivery speed. It comes across as frantic and it's difficult to take in what you're saying. It

  32. There is always some kind of feelings of insecurity or fear of failure exists behind every anxiety …. And so the idea of failure or loss of expected things creates the root to start depression… That's why anxiety and depression goes together most of the time…

  33. Could never really understand why mixed anxiety depressive disorder was not included in the DSM.
    After all, one form of Adjustment Disorder allows for a mixed presentation of anxiety and depression symptoms

  34. I had both in medium range. 2003, a big deal just to find out, “you have anxiety” by a Gestalt therapist. A 2008 psychiatrist committing truth: “when it comes to treatment we’re still in the dark ages.” 11 yrs later? They’re real big on stigma for good reason. Bc👆. Anti-psychs made things stupidly worse. Voluntary psych ward due to non-drug sleep deprivation also a big mistake. See Soderbergh’s “Unsane.” Corp. rehab & insurance scams + patient staff scams getting newbies to stay longer 2get insurance $. Film critics (a collective joke) went big on iPhone cam use in shooting the movie. Matt Damon did a cameo.

  35. Anxiety & insomnia together in “Where’d You Go Bernadette” out Aug 2019. Cate Blanchett via Richard Linklater. No John Wick bang bang MMA for excitable types. A good thing except that I also enjoyed John Wick(ed) Paralesspandamonium.

  36. I clicked on this just out of curiosity, and I found it to be somewhat helpful. It had statistics I hadn't been aware of, and chemical information that I can take to my doctor to learn more about. Overall, I found the content comforting. It touched on things I could relate too and sort of assured me that I'm on the right track. So thank you for the video. ^_^

  37. I'm anxious so I cannot sleep…and the lack of sleep causes me to feel depressed the next day…

    Vicious cycle…

  38. Exactly why do you edit in jump cuts? What do you expect to acheive other than put off some of your potential viewers/subscribers? Is it just idiocy or a follow the crowd (they'll think i'm cool) mentality?

  39. My first doctor diagnosed anxiety disorder, but ignored the debilitating depression which pissed me off. Later I had a seizure and the neurologist suggested another psychologist. This one suggested practicing mindfulness before trying any medication and it kind of was like a miracle switch off button for the anxiety. Just getting reigning in the anxiety itself has made me feel so much better

  40. Nothing felt worse then the time i admitted myself into a mental health facility, though the metal detector, "shoe laces off sir", ok, put in a locked waiting room (then was told i couldn't leave until i seen someone) with about 10 other people in there waiting… 7 hours later….david? "In here please"…im thinking finally some help?.. Some guidance? I'm lost and unraveling and finally I'm in the hands of someone to take the wheel…and just get me back to a functional form…
    A guy walks in the room sits across from me starring in the top opposite corner of the room and says in broken English….(Aggressively) " What you do?…What you want?".. with a robot demeaner….,him still starring at the opposite corner of the room…what little hope i had just deflated while i sat silently in awe of the cold slap of disappointment, now I'm starring at his mustard stain on his shirt while he briskly repeats himself,…and i say,(out of character, I'm always soft spoken and shy) i say firmly "just sign whatever paper needed to get me outta of here now"…" i obviously came to the wrong place"…The guy never once made eye contact, he signed a paper, and as i was being led out, a fellow patient my age (late 30's) "says don't leave!!… "Stay here for the night!" Im sure the look on my face,.. is what made him say exactly what i wanted to hear from the Doctor….that was two years ago, since then, i was fired from the best job i ever had, then my girl took our 3 girls and left me, i lost everything i ever owned, and now living out of a car….BIG CHANGES ARE NEEDED IN THE MENTAL HEALTH FIELD!!!

  41. She's a great speaker. Well done. These videos are usually long and dull and drag on and on, but she was engaging, spoke at a great speed, was interesting/informative, and got her message across perfectly.

  42. This can't be right.

    1. Let's assume T=1 (total population, 100%). A=0.03 (people with anxiety), D=0.07 (people with depression), see 1:05.
    2. M = mixed anxiety/depression. depression.
    3. If 2/3 of A is M and 2/3 of D is M (see 1:15) then 2/3*A=2/3*B, then A = B (this violates assumption #1).

    A possible correction of this contradiction:
    1. If 2/3 of depressed people have anxiety (2/3*D=M), then X of people with anxiety have depression X*A=M.
    2. 2/3*D=X*A
    3. 2/3*0.07=X*0.03
    4. X=2*7/9=1.5555… (155%)

    Lol. This can't be possible either.

    1. If 2/3 of anxious people have depression (2/3*A=M), then X of people with depression have anxiety X*D=M.
    2. 2/3*A=X*D
    3. 2/3*0.03=X*0.07
    4. X=2/7~0.28 (28%), this can be right.

    The numbers are LAME.

  43. Depression and anxiety are caused by low levels or unbalanced levels of 3 key neurotransmitters in the brain. Those neurotrasmitters are serotonin, dopamine and norepinephrine. To get the depression to remission you need a medication that works by increasing the trasmmition levels of those 3 neurotransmitters or by increasing only dopamine a lot. I know a few.

    -Selegiline is a MAOI-B that is a potent antidepressant that works by inhibing the monoamine oxidase which is responsible of removing those neurotrasmitters from the synapses. It will increase the level of of those 3 neurotransmitters and it takes a few weeks to fully work. It will work good on the anhedonia part of depression because is very dopaminergic and is also neuroprotective to dopaminergic neurons.

    -Fluoxetine (Prozac) is the only decent SSRI because is the only one that act potently on both serotonin and dopamine. When reach full effect it will improve mood and enhance pleasure noticeably. It has major downsides though. It could cause strong suicidal ideation in the beginning of the treatment in some people and the side effects could be harsh at first for some people. Takes quite some to to work like 4 to 6 weeks and it reach full effect at around 3 months. Is very cheap. It could cause for some people a strong withdrawal and long term anhedonia if is not tapered correctly.

    -Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA) that is effective for both depression and social anxiety. It mostly increase levels of serotonin and norepinephrine, and to a lesser extent dopamine too. It has a fast onset on action and is regarded as generally safe in adverse reactions and side effect are reported to be mild at the beginning of the treatment. The advantage of being a reversible maoi is that unlike irreversible maois like Nardil or Parnate, moclobemide almost don't interact with tyramine so no dietary restrictions are needed. It also has fewer interactions with other medications.

    -Tramadol is a weak mu opiod agonist and a SNRI. Is also theorized to be a serotonin releasing agent. This increases the levels of the 3 neurotransmitters but by different ways. All opioids or opiates releases large amounts of dopamine in the brain and by being an SNRI it also reuptake both serotonin and norepinephrine back to the synapse. Is commonly used as pain medication but is one of the most potent antidepressant in the world and it could make someone suicidal feel happy in matter of hours especially via IV. IV is 30% more potent than capsules or drops. It works very fast (1:30 hours) and the effect last 8 to 12 hours. Many people use it today as an antidepressant for years and only low doses are needed. It feels euphoric and is very anxiolitic. You will feel confident and optimistic about the future. The side effect are mild too but the downside is it could cause addiction and dependence, especially at higher doses and it could cause a strong withdrawal. For some people it could make them irritable or aggressive because of its action on norepinephrine. It could get tolerance for some or the antidepressant effect could pop out for some. Is very effective against all anxiety disorders, it can stop a panic or anxiety attack on its tracks. I'm referring here to the immediate release version of Tramadol, not the extended release.

    -Low dose of Amisulpride is an excellent medication for depression and anxiety and is used a lot for that purpose mainly in Italy. This is an antipsychotic that at the very low dose of 12.5 mg it only blocks the dopamine presynaptic autoreceptors which are in charge of clearing the dopamine from the synaptic cleft, thus blocking it will increase a lot the amounts of dopamine in the brain. I guess to be like 3 times to 5 times the amounts. So the difference will be massive and you will feel in another world very fast. It start working very fast in just 2 hours and the effect last all day. I felt no side effects. But it could get tolerance at first like in a week but the effect will usually return stronger at 4 to 6 weeks. People have reported to be working up to a year or so. Is very effective for social anxiety like Tramadol too.

    -Parnate is a MAOI-A that's is very effective for resistant depression and anxiety. This are the first type of antidepressant developed and it needs a dietary restriction because of it's dangerous interaction with tyramine. It works by increasing the levels of the 3 key neurotransmitters too. Selegiline by been a type B at low doses don't need a dietary restriction.

    -Nardil is another MAOI-A that works similar to Parnate but both have some different effects and advantages over the other. Is one of the most effective medications for social anxiety.

    -Mirapex is a dopamine agonist that is used mainly for Parkinson's but is also very effective for treatment resistant depression. It works by mimicking dopamine in the brain thus increasing the levels a lot. This will increase a lot your enjoyment and pleasure levels. Is one of the most potent antidepressants but it have some downsides. It could cause a condition called DAWS when stopping the med and this is potentially permanent in some. At first produce harsh side effects like nausea and dysphoria but they will go away with the days and it will start working like in 2 to 4 weeks. It could cause addictive behavior like for example compulsive gambling or sex addiction. This is kind of a last resource medication. https://youtu.be/jHA-Gu0ZtMQ

    -Ketamine is one of the most potent and faster antidepressant if not the most. Is both an anhastesic and recreational drug that act as a dissociative and hallucinogenic. It acts on many systems but mainly in glutamate and dopamine. It also promote neurogenesis and the grow of new neural connections. Is used today to save people who are suicidal in the ER and as a treatment for treatment resistant depression. It works very fast and is very effective. The effect of a single session last about a week or so. It will be approved soon by the FDA for depression. Unfortunately is quite expensive. https://youtu.be/Rux4d-32fUQ

    Psychological therapy is also recommended along side medication to address physiological issues like low self esteem for example. Exercise helps with depression and anxiety because it releases endorphins which are endogenous opiods of the brain and they promotes relaxation and feelings of well being. Socialization is also helpful.

    In the other hand some illegals drugs like MDMA or LSD are know to have cured or improved depression with only one dose in some people. Psylocibin act potently on serotonin and have been proven have an antidepressant effect by brain scans. https://youtu.be/oeNl0HjqAGo. Ayahuasca could be helpful for depression too because is basically DMT + MAOI-A. Each of those medications above could work for many years. Hope it helps

  44. Pro tip: pause clip after every half sentence because someone edited all the pauses out of this constant stream of information.

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